ࡱ> Y"bjbj[[".29 \9 \\ DDDDDXXX8TtXgKXnnnnIRJJJJJJJ+NPJJ-DIIJDDnn!K[?[?[?DnDnJ[?J[?[?AAn@ eia38AJ7K0gKA,+Q;x+QA+QDA [?JJ=JgK+Q P :">40B>: 2 4> B5=45@=>W 4>:C<5=B0FVW  "   !_______ @50;V70FVW :><?>=5=BV2 4>=>@AL:>W :@>2V B0 <548G=8E 28@>1V2 <. 8W2 202 @. ______________________________________________2 >A>1V___________________________, I> 4VT =0 ?V4AB02V ____________________________, I> V<5=CTBLAO =040;V 8:>=025FL 7 >4=VTW AB>@>=8, B0 ><C=0;L=5 =5:><5@FV9=5 ?V4?@8T<AB2> >=AC;LB0B82=>-4V03=>AB8G=89 F5=B@ =V?@>2AL:>3> @09>=C <. 8T20, 2 ?>40;LH><C >:C?5FL , 2 >A>1V 48@5:B>@ 0@010T20 0=V5;O "0W@>28G0, I> 4VT =0 ?V4AB02V !B0BCBC I> V<5=CTBLAO =040;V 0<>2=8:, 7 V=H>W AB>@>=8 (2 ?>40;LH><C  !B>@>=8), C:;0;8 F59 4>3>2V@ ?@> =0ABC?=5: 1.@54<5B 4>3>2>@C. 1.1.8:>=025FL 2V4?CA:0T 0<>2=8:C :><?>=5=B8 4>=>@AL:>W :@>2V B0 <548G=V 28@>18 4;O 4V03=>AB8:8 in vitro (40;V  @>4C:FVO), ?5@5;V: B0 :V;L:VABL O:8E 287=0G5=> C A?5F8DV:0FVW (>40B>:!1), O:0 T =52V4 T<=>N G0AB8=>N 40=>3> 4>3>2>@C, 0 0<>2=8:  ?@89<0T V >?;0GCT WE. 1.2.09<5=C20==O, :V;L:VABL B0 FV=0 @>4C:FVW 707=0G5=V 2 A?5F8DV:0FVO (>40B>: !1). 1.3.0<>2=8: 70<>2;OT C 8:>=02FO @>4C:FVN, 28E>4OG8 V7 =5>1EV4=>ABV 70157?5G5==O 9>3> @>4C:FVTN 2V4?>2V4=> 4> >@O4:C >B@8<0==O :><?>=5=BV2 4>=>@AL:>W :@>2V B0 <548G=8E 28@>1V2 4;O 4V03=>AB8:8 in vitro (40;V  >@O4>:) (>40B>:!3), O:89 T =52V4 T<=>N G0AB8=>N 40=>3> 4>3>2>@C. 2./:VABL B0 157?5:0. 2.1.8:>=025FL 30@0=BCT 0<>2=8:C, I> @>4C:FVO, O:0 2V4?CA:0TBLAO 0<>2=8:C, 2V4?>2V40T 70 E0@0:B5@8AB8:0<8 28<>30< G8==>3> 70:>=>402AB20 B0 >1AB565=0 =0 =0O2=VABL <0@:5@V2 B@0=ADC7V9=>-B@0=A<VA82=8E V=D5:FV9, 2V4?>2V4=> 4> 28<>3 =0:07C  #:@0W=8 2V4 08.02.2021@. !207 @> 2=5A5==O 7<V= 4> >@O4:C :0@0=B8=V70FVW 4>=>@AL:>W ?;07<8 B0 4> >@O4:C <548G=>3> >1AB565==O 4>=>@V2 :@>2V B0 (01>) WW :><?>=5=BV2. 3.#<>28 28:>=0==O 4>3>2>@C. 3.1.0<>2=8: 70<>2;OT @>4C:FVN C 8:>=02FO FV;>4>1>2> 70 B5;5D>=0<8 _____________, B0 =0 5;5:B@>==C 04@5AC 8:>=02FO __________________70 2V4?>2V4=>N D>@<>N (>40B>:!2). 3.2.V4?CA: @>4C:FVW 74V9A=NTBLAO 2V4?>2V4=> 4> =040=>W 0<>2=8:>< =0;56=> >D>@<;5=>W 0O2:8 =0 :><?>=5=B8 4>=>@AL:>W :@>2V B0 <548G=V 28@>18 4;O 4V03=>AB8:8 in vitro (>40B>:!2) B0 2V4?>2V4=> 4> >@O4:C >B@8<0==O :><?>=5=BV2 4>=>@AL:>W :@>2V B0 <548G=8E 28@>1V2 4;O 4V03=>AB8:8 in vitro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in vitro (>40B>:!2);  <0B8 V7>B5@<VG=V :>=B59=5@8 (>:@5<> 4;O 5@8B@>F8B0@=8E, ?;07<>28E, B@><1>F8B0@=8E :><?>=5=BV2 4>=>@AL:>W :@>2V);  <0B8 B5@<><5B@8 01> V=HV A5@B8DV:>20=V ?@8AB@>W 4;O :>=B@>;N B5<?5@0BC@8 ?V4 G0A B@0=A?>@BC20==O :><?>=5=BV2 4>=>@AL:>W :@>2V 7 2V4?>2V4=8<8 4V0?07>=0<8 28<V@N20==O;  <0B8 E>;>4>035=B8 (0:C<C;OB>@8 E>;>4C) @V7=>3> B8?C I> 70AB>A>2CNBLAO 2V4?>2V4=> 4> 284C :><?>=5=B0 4>=>@AL:>W :@>2V I> B@0=A?>@BCTBLAO (5@8B@>F8B0@=>3>, ?;07<>2>3>, B@><1>F8B0@=>3>) B0 V=HV 70A>18, O:V ?5@5410G5=V >@O4:>< (>40B>:! 3). # @07V =528:>=0==O 40=8E 28<>3 8:>=025FL 70;8H0T 70 A>1>N ?@02> =5 284020B8 @>4C:FVN C?>2=>2065=><C ?@54AB02=8:C (>B@8<C20GC) 7V AB>@>=8 0<>2=8:0. 3.9.>1>2 O70==O 8:>=02FO ?> 70157?5G5==N 0<>2=8:0 @>4C:FVTN =0;56=>W O:>ABV B0 157?5:8 22060TBLAO 28:>=0=8< ?VA;O ?5@540GV @>4C:FVW 8:>=02F5< C?>2=>2065=><C ?@54AB02=8:C (>B@8<C20GC) 7V AB>@>=8 0<>2=8:0 B0 ?V4?8A0==O =8< =0:;04=>W =0 2V4?CA: <0B5@V0;V2 =0 AB>@>=C. 3.10."@0=A?>@BC20==O @>4C:FVW C73>46CTBLAO 0<>2=8:>< 7 8:>=02F5< B0 74V9A=NTBLAO 0<>2=8:><. 3.11.4V9A=NNG8 B@0=A?>@BC20==O @>4C:FVW 0<>2=8: 70157?5GCT WW 715@565==O B0 O:VABL ?V4 G0A B@0=A?>@BC20==O, 2V4?>2V4=> 4> 28<>3 ?5@52575==O ?@>4C:FVW, 707=0G5=8E 2 >@O4:C (>40B>:!3) B0 =5A5 2AV 28B@0B8 V @878:8 C @07V 9>3> ?AC20==O. 4.&V=0 4>3>2>@C 4.1.&V=0 =0 @>4C:FVN 2AB0=>2;NTBLAO 2 =0FV>=0;L=V9 20;NBV #:@0W=8. 0;NB>N 4>3>2>@C T 3@82=O #:@0W=8. 4.2.030;L=0 AC<0 4>3>2>@C AB0=>28BL ______________________ 3@=. (_________________________________________ 3@=. ____________ :>?.) 157 . B0 A:;040TBLAO V7 2AVE 4>3>2V@=8E 20@B>AB59 2AVE ?0@BV9 @>4C:FVW, ?>AB02:8 O:8E 74V9A=5=V 2V4?>2V4=> 4> FL>3> >3>2>@C B0 @>7@0E>2CTBLAO H;OE>< A:;040==O 2V4?CA:=8E AC<, 707=0G5=8E C 2840B:>28E =0:;04=8E =0 2AV ?>AB02:8 @>4C:FVW ?@>BO3>< AB@>:C 4VW FL>3> >3>2>@C, 157 . 4.3.&V=0 =0 ?@>4C:FVN 287=0G5=0 2 A?5F8DV:0FVW V <>65 7<V=N20B8AO 2V4?>2V4=> 4> :>;820=L 70:C?V25;L=8E FV= =0 28B@0B=V <0B5@V0;8, ?V428I5==O FV= =0 5;5:B@>5=5@3VN B0 :><C=0;L=V ?>A;C38. 4.4.# 28?04:0E 7<V=8 FV=8 !B>@>=0<8 C:;040TBLAO 4>40B:>20 C3>40, O:0 T =52V4 T<=>N G0AB8=>N 40=>3> 4>3>2>@C. 5.>@O4>: 74V9A=5==O >?;0B8 5.1. 84 @>7@0EC=:V2  1573>BV2:>289 . 5.2. $>@<0 @>7@0EC=:C  ?;0BV6=5 4>@CG5==O. 5.3. >7@0EC=>: 74V9A=NTBLAO C 1573>BV2:>2V9 D>@<V H;OE>< ?5@5@0EC20==O 0<>2=8:>< 3@>H>28E :>HBV2 =0 ?>B>G=89 @0EC=>: 8:>=02FO. 5.4. >7@0EC=:8 70 =040=V ?>A;C38 74V9A=NNBLAO =0 ?V4AB02V 2840B:>2>W =0:;04=>W B0/01> 0:BC ?@89<0==O-?5@540GV =040=8E ?>A;C3, =0 C<>20E 2V4AB@>G:8 ?;0B56C ?@>BO3>< 15 10=:V2AL:8E 4=V2, 7 4=O >B@8<0==O 2840B:>2>W =0:;04=>W/0:BC ?@89<0==O-?5@540GV =040=8E ?>A;C3. 5.5. # @07V 70B@8<0==O DV=0=AC20==O @>7@0EC=>: 74V9A=NTBLAO ?@>BO3>< 5-B8 10=:V2AL:8E 4=V2 7 4=O >B@8<0==O 0<>2=8:>< :>HBV2 =0 DV=0=AC20==O 70:C?V2;V =0 A2V9 @>7@0EC=:>289 @0EC=>:. "0:V C<>28 DV=0=AC20==O 28:;NG0NBL ?@54 O2;5==O HB@0D=8E A0=:FV9 I>4> >?;0B8 70 >B@8<0==O ?@>4C:FVW. 6.@020 B0 >1>2 O7:8 AB>@V= 6.1.8:>=025FL 7>1>2 O70=89: ?5@540B8 2 @>7?>@O465==O 0<>2=8:C ?@>4C:FVN 2V4?>2V4=> 4> =0:;04=>W; 6.2.0<>2=8: 7>1>2 O70=89: 701@0B8 @>4C:FVN B0 A2>TG0A=> V 2 ?>2=><C >1AO7V 74V9A=8B8 >?;0BC 70 >45@60=C @>4C:FVN 2 ?>@O4:C 287=0G5=><C 4>3>2>@><. 7.V4?>2V40;L=VABL AB>@V= 7.1.# @07V =5 28:>=0==O 01> =5=0;56=>3> 28:>=0==O A2>WE 7>1>2 O70=L 70 4>3>2>@>< !B>@>=8 =5ACBL 2V4?>2V40;L=VABL, ?5@5410G5=C G8==8< 70:>=>402AB2><. 7.2.0 ?>@CH5==O C<>2 >3>2>@C !B>@>=8 A?;0GCNBL :><?5=A0FVN 2V4?>2V4=> 4> G0AB8=8 4@C3>W AB0BBV 625 & #:@0W=8, 0 A0<5 >@6=8: O:89 ?@>AB@>G82 28:>=0==O 3@>H>2>3> 7>1>2'O70==O, =0 28<>3C :@548B>@0 7>1>2'O70=89 A?;0B8B8 AC<C 1>@3C 7 C@0EC20==O< 2AB0=>2;5=>3> V=45:AC V=D;OFVW 70 25AL G0A ?@>AB@>G5==O, 0 B0:>6 B@8 ?@>F5=B8 @VG=8E 2V4 ?@>AB@>G5=>W AC<8, O:I> V=H89 @>7<V@ ?@>F5=BV2 =5 2AB0=>2;5=> 4>3>2>@>< 01> 70:>=><. 8.1AB028=8 =5?5@51>@=>W A8;8 8.1.!B>@>=8 72V;L=NNBLAO 2V4 2V4?>2V40;L=>ABV 70 G0AB:>25 G8 ?>2=5 =528:>=0==O >1>2 O7:V2 70 F8< 4>3>2>@><, O:I> 2>=8 B@0?8;8AL 2=0A;V4>: >1AB028= =5?5@51>@=>W A8;8 (D>@A-<06>@=8E >1AB028=). 8.2.V4 D>@A-<06>@=8<8 >1AB028=0<8 @>7C<VNBL 7>2=VH=V B0 =04728G09=V >1AB028=8, O:V =5 VA=C20;8 =0 G0A ?V4?8A0==O FL>3> 4>3>2>@C, 28=8:;8 ?>70 2>;5N !B>@V=, =0AB0==N B0 4VW O:8E 2>=8 =5 <>3;8 ?5@5H:>48B8 70 4>?><>3>N 70E>4V2 B0 70A>1V2, 70AB>AC20==O O:8E C :>=:@5B=V9 A8BC0FVW A?@0254;82> 28<030B8 B0 G5:0B8 2V4 !B>@>=8, I> ?V4?0;0 ?V4 4VN D>@A-<06>@=8E >1AB028=. 8.3.$>@A-<06>@=8<8 >1AB028=0<8 287=0NBL B0:V >1AB028=8: ?>656V, ?>25=V, 75<;5B@CA8, 5?V45<VW, 020@VW =0 B@0=A?>@BV, 4825@AVW, 2V9=0 B0 2V9AL:>2V 4VW, 0:B8 >@30=V2 2;048, B>I>. 8.4.!B>@>=8 <>6CBL 1CB8 72V;L=5=V 2V4 2V4?>2V40;L=>ABV 70 G0AB:>25 G8 ?>2=5 =528:>=0==O >1>2 O7:V2 70 F8< 4>3>2>@><, O:I> 4>254CBL, I> 2>=> 1C;> 28:;8:0=5 ?5@5H:>4>N ?>70 WE :>=B@>;5<, O:V9 =02VBL C206=0 !B>@>=0 =5 <>3;0 1 70?>1V3B8, V 28=8:;> ?VA;O C:;045==O FL>3> 4>3>2>@C. 8.5."5@<V= 28:>=0==O >1>2 O7:V2 70 F8< 4>3>2>@>< 2V4:;040TBLAO ?@8 28=8:=5==V >1AB028=, 707=0G5=89 C ?C=:B0E 8.1. 8.3., =0 G0A ?@>BO3>< O:>3> >AB0==V 1C4CBL 4VOB8. 8.6.!B>@>=0, I> ?V4?0;0 ?V4 4VN D>@A-<06>@=8E >1AB028= V 28O28;0AL 2=0A;V4>: FL>3> =5740B=>N 28:>=C20B8 >1>2 O7:8 70 F8< 4>3>2>@><, ?>28==0 B5@<V=>2>, =5 ?V7=VH5 5 4=V2 7 <><5=BC WE =0AB0==O, C ?8AL<>2V9 D>@<V ?>2V4><8B8 V=HC !B>@>=C. 5A2>TG0A=5, 1V;LH5 =V6 5 4=V2, ?>2V4><;5==O ?@> D>@A-<06>@=V >1AB028=8 ?>7102;OT 2V4?>2V4=C !B>@>=C ?@020 ?>A8;0B8AO =0 =8E 4;O 28?@0240==O. 8.7.0;56=8< 4>:07>< >1AB028=, 707=0G5=8E C ?C=:B0E 8.1. 8.3. B0 AB@>:C WE 4VW A;C3CNBL 4>2V4:8, O:V 2840NBLAO 2V4?>2V4=>N B>@3>2>N ?0;0B>N G8 ?>2=>206=8<8 >@30=0<8 <VAF52>3> (70 <VAF5< D>@A-<06>@=8E >1AB028=) 45@602=>W 04<V=VAB@0FVW. 8.8./:I> >1AB028=8, 707=0G5=V C ?C=:B0E 8.1. 8.3. FL>3> 4>3>2>@C, 1C4CBL ?@>4>26C20B8AO 1V;LH5 30 4=V2, B> :>6=0 V7 !B>@V= 1C45 2?@02V @>7V@20B8 4>3>2V@ ?>2=VABN G8 G0AB:>2>, V 2 B0:><C 28?04:C 6>4=0 V7 !B>@V= =5 1C45 <0B8 ?@020 28<030B8 2V4 V=H>W 2V4H:>4C20==O <>6;828E 718B:V2. !B>@>=8 7>1>2 O7CNBLAO, ?@8 FL><C, C B5@<V= 5 10=:V2AL:8E 4=V2 ?@>25AB8 >AB0B>G=V 270T<>@>7@0EC=:8, O:I> <V6 =8<8 VA=CT 701>@3>20=VABL. 9.8@VH5==O A?>@V2 9.1.# 28?04:C 28=8:=5==O A?>@V2 01> @>71V6=>AB59 !B>@>=8 7>1>2 O7CNBLAO 28@VHC20B8 WE H;OE>< 270T<=8E ?5@53>2>@V2 B0 :>=AC;LB0FV9. 9.2.# @07V =54>AO3=5==O !B>@>=0<8 73>48 A?>@8 (@>71V6=>ABV) 28@VHCNBLAO C AC4>2><C ?>@O4:C, 2V4?>2V4=> 4> G8==>3> 70:>=>402AB20 #:@0W=8. 10.!B@>:8 4VW 4>3>2>@C. 10.1.&59 >3>2V@ =018@0T G8==>ABV 7 <><5=BC 9>3> ?V4?8A0==O !B>@>=0<8 V 4VT 4> 31 3@C4=O 2024 @. 0;5 C 1C4L-O:><C 28?04:C 4> ?>2=>3> 9>3> 28:>=0==O. 10.2.&59 >3>2V@ A:;045=89 C 42>E >@83V=0;L=8E ?@8<V@=8:0E, O:V <0NBL >4=0:>2C N@848G=C A8;C, ?> >4=><C 4;O :>6=>W V7 !B>@V=. 10.3.&59 >3>2V@ <>65 1CB8 @>7V@20=89 =0 28<>3C 1C4L-O:>W V7 AB>@V=, ?@> I> !B>@>=0, O:0 1060T @>7V@20B8 >3>2V@, ?8AL<>2> ?>2V4><;OT 4@C3C !B>@>=C 70 14 @>1>G8E 4=V2. 11.=HV C<>28 11.1. <V=8 4> 4>3>2>@C ?@> 70:C?V2;N >D>@<;ONBLAO H;OE>< C:;040==O 2V4?>2V4=>W 4>40B:>2>W C3>48, O:0 ?V4?8ACTBLAO C?>2=>2065=8<8 ?@54AB02=8:0<8 >1>E !B>@V=, A:@V?;NTBLAO ?5G0B:0<8 !B>@V= (70 =0O2=>ABV) B0 T =52V4`T<=>N G0AB8=>N >3>2>@C. 11.2. @>?>78FVN I>4> 2=5A5==O 7<V= 4> 4>3>2>@C <>65 7@>18B8 :>6=0 V7 AB>@V= 4>3>2>@C. 11.3. @>?>78FVO I>4> 2=5A5==O 7<V= 4> 4>3>2>@C <0T <VAB8B8 >1@C=BC20==O =5>1EV4=>ABV 2=5A5==O B0:8E 7<V= 4>3>2>@C V 28@060B8 =0<V@ >A>18, O:0 WW 7@>18;0, 22060B8 A515 7>1>2'O70=>N C @07V WW ?@89=OBBO. 1<V= V=D>@<0FVTN I>4> 2=5A5==O 7<V= 4> 4>3>2>@C 74V9A=NTBLAO C ?8AL<>2V9 D>@<V H;OE>< 270T<=>3> ;8ABC20==O. 11.4. <V=0 4>3>2>@C 4>?CA:0TBLAO ;8H5 70 73>4>N AB>@V=, O:I> V=H5 =5 2AB0=>2;5=> 4>3>2>@>< 01> 70:>=><.  B>9 65 G0A, 4>3>2V@ <>65 1CB8 7<V=5=> 01> @>7V@20=> 70 @VH5==O< AC4C =0 28<>3C >4=VTW V7 AB>@V= C @07V VAB>B=>3> ?>@CH5==O 4>3>2>@C 4@C3>N AB>@>=>N B0 2 V=H8E 28?04:0E, 2AB0=>2;5=8E 4>3>2>@>< 01> 70:>=><. 11.5. AB>B=V C<>28 4>3>2>@C =5 <>6CBL 7<V=N20B8AO ?VA;O 9>3> ?V4?8A0==O 4> 28:>=0==O 7>1>2 O70=L AB>@>=0<8 2 ?>2=><C >1AO7V, :@V< 28?04:V2: -. 7<5=H5==O >1AO3V2 70:C?V2;V, 7>:@5<0 7 C@0EC20==O< D0:B8G=>3> >1AO3C 2840B:V2 70<>2=8:0; - ?>3>465==O 7<V=8 FV=8 d   b d n p r  < t   0 4 P R l n x z ǾǴ~ h,PJh{ h,PJ h,PJhzph,PJ h,5PJh{ h,5PJ h,5PJh{ h,5PJ hf5h,hf h,5 hX5hfCJaJh,(5>*\hf5>*\ hf\ hf5\ h u5\1LN\^`bd    l n _kd$$IfF te)   6    44 la $$Ifa$$If$a$$a$gd un p r X Z T0rR j!!"$`a$ $`a$m$$a$m$ $7`7a$gd,$7`7a$$a$ B F J L R T X Z j l z  X Z LNl~dt68JL^n$>4602¾%hf5B*CJ \aJ nHph333tHh;hfCJaJ h$\h$\h7Oh\/hB h$\\ hf\ hf5\hfCJaJ hf5hfhzph,PJ h,PJhzph,PJ924"F <N h!!++11<1X222222222 3(3*3,3R5T57îhN#2h#5\h4 h Ed5\ hp+5\h/h#5\ h#5\h# hfCJho  hf6H* hf5\ *hfhfCJaJ h$\h$\h,5>*B*ph hf5 h,5hfhfB*ph/"$v%% ''B)$+P,r.4/11<1 2T567772889$`a$^ $`a$gdN#2 $`a$gd#$a$ $ 7`a$$`a$777==>>0>~>>>>@@<@DD2V4V\V^V XxXzX|XXXbYfYlYrYYYZZZZ(\*\H\J\{o{fhWQ5nHtHhfmHnHsHtHhfh<#nHtHhnHtHhN#2nHtHh&1nHtHh<hfnHtH+hfaJfHmHnH q sHtH #hfaJfHnH q tH hfCJaJnHtHh&15nHtHhfnHtHhf5nHtHhfCJaJ(9;==>>@@<@hADDDtFNIJL$NQR2V4V\V^VfW$`a$$a$$`a$fWzX|XXYZ*\,\b\B^^`ac$xd]x^`a$gdWQ$x7d]x^`7a$gdWQ$q71$]q^`7a$gdWQ$a$gdWQ$a$$`a$$ 71$]`7a$ J\b\l\D^F^badaccddeee|XZjlNPrt "z|*,bdLNjlŮŮŮŜ} hWQhWQPJmHnHsHtHhWQhWQPJ\nH tH #hWQhWQPJ\mHnH sHtH )jhWQhWQPJUmHnH sHtH U hWQhWQPJmHnH sHtH hWQhWQPJnH tH 7hWQhWQ5CJPJ\aJfHq sHtH.cdeXjNr JИLNP$`a$$a$$d`a$gdWQ$d^`a$gdWQm$2$ 8( Px 4 #\'*.25@9d^`a$gdWQ70 >48=8FN B>20@C 2 4>3>2>@V ?@> 70:C?V2;N C @07V :>;820==O FV=8 B0:>3> B>20@C =0 @8=:C, I> 2V41C;>AO 7 <><5=BC C:;045==O 4>3>2>@C ?@> 70:C?V2;N 01> >AB0==L>3> 2=5A5==O 7<V= 4> 4>3>2>@C ?@> 70:C?V2;N 2 G0AB8=V 7<V=8 FV=8 70 >48=8FN B>20@C. <V=0 FV=8 70 >48=8FN B>20@C 74V9A=NTBLAO ?@>?>@FV9=> :>;820==N FV=8 B0:>3> B>20@C =0 @8=:C (2V4A>B>: 71V;LH5==O FV=8 70 >48=8FN B>20@C =5 <>65 ?5@528IC20B8 2V4A>B>: :>;820==O (71V;LH5==O) FV=8 B0:>3> B>20@C =0 @8=:C) 70 C<>28 4>:C<5=B0;L=>3> ?V4B25@465==O B0:>3> :>;820==O B0 =5 ?>28==0 ?@8725AB8 4> 71V;LH5==O AC<8, 287=0G5=>W 2 4>3>2>@V ?@> 70:C?V2;N =0 <><5=B 9>3> C:;045==O. 0=89 28?04>: =5 70AB>A>2CTBLAO ?@8 70:C?V2;V @>1VB G8 ?>A;C3; - ?>:@0I5==O O:>ABV ?@54<5B0 70:C?V2;V 70 C<>28, I> B0:5 ?>:@0I5==O =5 ?@872545 4> 71V;LH5==O AC<8, 287=0G5=>W 2 4>3>2>@V ?@> 70:C?V2;N; - ?@>4>265==O AB@>:C 4VW 4>3>2>@C ?@> 70:C?V2;N B0/01> AB@>:C 28:>=0==O 7>1>2 O70=L I>4> ?5@540GV B>20@C, 28:>=0==O @>1VB, =040==O ?>A;C3 C @07V 28=8:=5==O 4>:C<5=B0;L=> ?V4B25@465=8E >1 T:B82=8E >1AB028=, I> A?@8G8=8;8 B0:5 ?@>4>265==O, C B><C G8A;V >1AB028= =5?5@51>@=>W A8;8, 70B@8<:8 DV=0=AC20==O 28B@0B 70<>2=8:0, 70 C<>28, I> B0:V 7<V=8 =5 ?@87254CBL 4> 71V;LH5==O AC<8, 287=0G5=>W 2 4>3>2>@V ?@> 70:C?V2;N; - ?>3>465==O 7<V=8 FV=8 2 4>3>2>@V ?@> 70:C?V2;N 2 1V: 7<5=H5==O (157 7<V=8 :V;L:>ABV (>1AO3C) B0 O:>ABV B>20@V2, @>1VB V ?>A;C3); - 7<V=8 FV=8 2 4>3>2>@V ?@> 70:C?V2;N C 72 O7:C 7 7<V=>N AB02>: ?>40B:V2 V 71>@V2 B0/01> 7<V=>N C<>2 I>4> =040==O ?V;L3 7 >?>40B:C20==O  ?@>?>@FV9=> 4> 7<V=8 B0:8E AB02>: B0/01> ?V;L3 7 >?>40B:C20==O, 0 B0:>6 C 72 O7:C 7 7<V=>N A8AB5<8 >?>40B:C20==O ?@>?>@FV9=> 4> 7<V=8 ?>40B:>2>3> =020=B065==O 2=0A;V4>: 7<V=8 A8AB5<8 >?>40B:C20==O; - 7<V=8 2AB0=>2;5=>3> 73V4=> V7 70:>=>402AB2>< >@30=0<8 45@602=>W AB0B8AB8:8 V=45:AC A?>682G8E FV=, 7<V=8 :C@AC V=>75<=>W 20;NB8, 7<V=8 1V@6>28E :>B8@C20=L 01> ?>:07=8:V2 Platts, ARGUS, @53C;L>20=8E FV= (B0@8DV2), =>@<0B82V2, A5@54=L>72065=8E FV= =0 5;5:B@>5=5@3VN =0 @8=:C  =0 4>1C =0?5@54 , I> 70AB>A>2CNBLAO 2 4>3>2>@V ?@> 70:C?V2;N, C @07V 2AB0=>2;5==O 2 4>3>2>@V ?@> 70:C?V2;N ?>@O4:C 7<V=8 FV=8; - ?@>4>265==O 4VW >3>2>@C ?@> 70:C?V2;N =0 AB@>:, 4>AB0B=V9 4;O ?@>2545==O ?@>F54C@8 70:C?V2;V/A?@>I5=>W 70:C?V2;V =0 ?>G0B:C =0ABC?=>3> @>:C 2 >1AO7V, I> =5 ?5@528ICT 20 2V4A>B:V2 AC<8, 287=0G5=>W 2 ?>G0B:>2><C 4>3>2>@V ?@> 70:C?V2;N, C:;045=><C 2 ?>?5@54=L><C @>FV, O:I> 2840B:8 =0 4>AO3=5==O FVTW FV;V 70B25@465=> 2 CAB0=>2;5=><C ?>@O4:C. - 7<5=H5==O >1AO3V2 70:C?V2;V B0/01> FV=8 73V4=> 7 4>3>2>@0<8 ?@> 70:C?V2;N @>1VB 7 1C4V2=8FB20 >1 T:BV2 =5@CE><>3> <09=0 2V4?>2V4=> 4> ?>AB0=>28 01V=5BC V=VAB@V2 #:@0W=8 HYPERLINK "https://zakon.rada.gov.ua/laws/show/382-2023-%D0%BF" \l "Text" \t "_blank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mail:"5;.: 0<>2=8:: >HB>20 04@5A0 B0 V=45:A:"5;./D0:A: >7@0EC=:>289 @0EC=>::! UA>4 10=:C :>4  #E-mail:"5;.: 8:>=025FL:0<>2=8:: >40B>:!1 4> >3>2>@C !___________ 2V4 _________________202__@. 0;L:C;OFVO 8:>=025FL:0<>2=8:: >4 ?>A;C3809<5=C20==O ?@>4C:FVW 48=8FO 28<V@C-BL&V=0 70 >48=8FN (3@=.)!C<0 (3@=.)@8B@>F8B8 C 4>40B:>2><C @>7G8=V (250 <; +- 50 <; + 100 <;. !)  4>70 !,: 030;L=0 AC<0 4>3>2>@C AB0=>28BL: __________________________________________________________________________________3@=, 157 (?@>?8A><) 8:>=025FL:0<>2=8::________________  >40B>:!2 4> >3>2>@C !___________ 2V4________________20__ @. 0O2:0 =0 :><?>=5=B8 4>=>@AL:>W :@>2V B0 <548G=V 28@>18 4;O 4V03=>AB8:8 in vitro __________________________________________________________________________________ (70:;04 >E>@>=8 74>@>2 O, I> 70<>2;OT) 0B0 70<>2;5==O __________________________20_____@. ! 7/?09<5=C20==O :><?>=5=BC 4>=>@AL:>W :@>2V/28@>1C <548G=>3> ?@87=0G5==O@C?>20 =0;56=VABL 57CA =0;56=VABL48=8FO 28<V@CV;L:VABL     #?>2=>2065=0 >A>10 7 =040==O B@0=ADC7V>;>3VG=>W 4>?><>38/2V4?>2V40;L=89 G5@3>289 ;V:0@ _____________________ ___________________ (?V4?8A) (...) 8@5:B>@/0ABC?=8: 48@5:B>@0 (2V4?>2V40;L=89 70 :>=B@>;L =040==O ?>A;C3 7 B@0=ADC7VW :><?>=5=BV2 4>=>@AL:>W :@>2V) _______________________ ___________________ (?V4?8A) (...) .. #?>2=>2065=89 >45@6C20G _____________________ ___________________ (?V4?8A) (...) >:C<5=B, I> 70A2V4GCT >A>1C  >45@6C20G0 _________________, A5@VO __________, ! ____________, :8< 2840=89 _____________________________________________________, 40B0 2840GV ___________ >40B>:!3 4> >3>2>@C !___________ 2V4 _________________20__ @.  / >B@8<0==O :><?>=5=BV2 4>=>@AL:>W :@>2V B0 <548G=8E 28@>1V2 4;O 4V03=>AB8:8 in vitro 1.0:;048 >E>@>=8 74>@>2 O 70157?5GCNBLAO :><?>=5=B0<8 4>=>@AL:>W :@>2V B0 <548G=8<8 28@>10<8 4;O 4V03=>AB8:8 in vitro 2.;O 70:;04V2 >E>@>=8 74>@>2 O 2840G0 :><?>=5=BV2 4>=>@AL:>W :@>2V B0 <548G=8E 28@>1V2 4;O 4V03=>AB8:8 in vitro 74V9A=NTBLAO ______________________ =0 ?V4AB02V 4>:C<5=BC 0O2:0 =0 :><?>=5=B8 4>=>@AL:>W :@>2V B0 <548G=V 28@>18 4;O 4V03=>AB8:8 in vitro (40;V  0O2:0), 702V@5=>3> ?V4?8A>< :5@V2=8:0 (70ABC?=8:0) B0 ?5G0B:>N 70:;04C >E>@>=8 74>@>2 O (>40B>: !2 4> 4>3>2>@C).  5:AB@5=V9 A8BC0FVW 01> 2 =VG=89 G0A, 28EV4=V B0 A2OB:>2V 4=V ?@02> ?V4?8AC =0 707=0G5=><C 4>:C<5=BV =040TBLAO 2V4?>2V40;L=><C G5@3>2><C ;V:0@N 70:;04C >E>@>=8 74>@>2 O. 3."@0=A?>@BC20==O :><?>=5=BV2 4>=>@AL:>W :@>2V ?>28==5 74V9A=N20B8AO ?5@A>=0;><, O:89 =5A5 2V4?>2V40;L=VABL 70 >B@8<0=V <0B5@V0;L=V FV==>ABV, 4>B@8<0==O ?@028; B@0=A?>@BC20==O B0 ?@>9H>2 2V4?>2V4=89 V=AB@C:B06. 4.8<>38 4> B@0=A?>@BC20==O ?@>4C:BV2 4>=>@AL:>W :@>2V B0 <548G=8E 28@>1V2 4;O 4V03=>AB8:8 in vitro (40;V  @>4C:FVW): ;O :>=B@>;N B5<?5@0BC@8 A;V4 28:>@8AB>2C20B8 B5@<><5B@8 01> V=HV A5@B8DV:>20=V ?@8AB@>W :>=B@>;N ?V4 G0A B@0=A?>@BC20==O :><?>=5=BV2 4>=>@AL:>W :@>2V 7 2V4?>2V4=8<8 4V0?07>=0<8 28<V@N20==O B0 E>;>4>035=B8 (0:C<C;OB>@8 E>;>4C) @V7=>3> B8?C I> 70AB>A>2CNBLAO 2V4?>2V4=> 4> 284C :><?>=5=B0 4>=>@AL:>W :@>2V I> B@0=A?>@BCTBLAO (5@8B@>F8B0@=>3>, ?;07<>2>3>, B@><1>F8B0@=>3>). "@0=A?>@BC20==O 5@8B@>F8B0@=8E :><?>=5=BV2 :@>2V. %>;>4>035=B, O:89 7=0E>48BLAO 2 B5@<>:>=B59=5@V =5 ?>28=5= B>@:0B8AO 35<>:>=B59=5@0 7 5@8B@>F8B0<8. "><C ?@8 WE B@0=A?>@BC20==V =5>1EV4=> 28:>@8AB>2C20B8 2V4?>2V4=V ?0:C20;L=V <0B5@V0;8 B0 ?@>2>48B8 ?@028;L=5 ?0:C20==O. >?CAB8<0 B5<?5@0BC@0 C B5@<>:>=B59=5@V ?>28==0 ?V4B@8<C20B8AL 2 4V0?07>=V 2V4 +2! 4> +6!. 0;V4>20=V B5@<>:>=B59=5@8 4;O ?5@52575=L ?>28==V 70157?5GC20B8 C<>28, I>1 =0?@8:V=FV <0:A8<0;L=>3> G0AC ?5@52575==O (24 3>48=8) B5<?5@0BC@0 2 :>=B59=5@V =5 ?5@528IC20;0 10! B0 =5 >?CA:0;0AL =86G5 +1!. /:I> 5@8B@>F8B8 =5 ?V4;O30NBL =5309=><C 28:>@8AB0==N, WE =5>1EV4=> 715@V30B8 2 E>;>48;L=8:C ?@8 B5<?5@0BC@V 2V4 +2! 4> +6!. "@0=A?>@BC20==O ?;07<>28E :><?>=5=BV2 4>=>@AL:>W :@>2V. V4 G0A B@0=A?>@BC20==O 206;82> 70157?5G8B8 =04V9=89 70E8AB 4>7 A2V6>70<>@>65=>W ?;07<8 B0 :@V>?@5F8?VB0BC. ;07<0 ?>28==0 B@0=A?>@BC20B8AO C 70<>@>65=><C AB0=V ?@8 B5<?5@0BC@V, I> <0:A8<0;L=> =01;865=0 4> B5<?5@0BC@8 715@V30==O. 15@V30==O ?;07<8 A2V6>70<>@>65=>W B0 :@V>?@5F8?VB0BC ?@8 B5<?5@0BC@V 2V4 <V=CA 25 ! B0 =86G5 A:;040T 36 <VAOFV2, ?@8 B5<?5@0BC@V 2V4 <V=CA 18! 4> <V=CA 25!  3 <VAOFV. /:I> ?;07<0 =5 ?V4;O30T =5309=><C 28:>@8AB0==N, WW =5>1EV4=> 715@V30B8 2 =87L:>B5<?5@0BC@=><C E>;>48;L=8:C ?@8 B5<?5@0BC@V <V=CA 30! B0 =86G5. "@0=A?>@BC20==O B@><1>F8B0@=8E :><?>=5=BV2 4>=>@AL:>W :@>2V. "5@<>:>=B59=5@8 4;O B@0=A?>@BC20==O B@><1>F8BV2 ?5@54 28:>@8AB0==O< ?>28==V 1CB8 2V4@53C;L>20=V =0 B5<?5@0BC@C 2V4 +20! 4> +24!. /:I> 7>2=VH=O B5<?5@0BC@0 T 4C65 28A>:>N, <>6=0 28:>@8AB>2C20B8 A?5FV0;L=V >E>;>46C20;L=V ?@8AB@>W, :>B@V <>6CBL B@0=A?>@BC20B8AO @07>< 7 B@><1>F8B0<8 B0 ?V4B@8<C20B8 B5<?5@0BC@C 2V4 +20! 4> +24! =5 1V;LH =V6 12 3>48=. A=CNBL B0:>6 :>=B59=5@8, O:V 682;OBLAO 2V4 465@5;0 5;5:B@>5=5@3VW V :>B@V ?V4B@8<CNBL B5<?5@0BC@C C 4V0?07>=V 2V4 +20! 4> +24!. "@><1>F8B8 ?>28==V 4>AO3B8 ?C=:BC ?@87=0G5==O C?@>4>26 24 3>48=, I> T <0:A8<0;L=> 4>?CAB8<8< G0A>< B@0=A?>@BC20==O 157 <5E0=VG=>3> ?5@5<VHC20==O. V@CAV=0:B82>=0=V B@><1>F8B8 =5>1EV4=> 70E8I0B8 2V4 2?;82C ?@O<8E A>=OG=8E ?@><5=V2 B0 ?>BC6=8E 465@5; HBCG=>3> A2VB;0. "@><1>F8B8 715@V30NBLAO ?@8 B5<?5@0BC@V 2V4 +20! 4> +24! 70 C<>28 >15@56=>3> ?5@V>48G=>3> ?><VHC20==O 2 B@><1>H59:5@V. /:I> 70:;048 >E>@>=8 74>@>2 O =5 <0NBL C<>2 4;O 715@V30==O B@><1>F8BV2, 2>=8 ?>28==V 1CB8 28:>@8AB0=V =5309=>. "@0=A?>@BC20==O <548G=8E 28@>1V2 4;O 4V03=>AB8:8 in vitro. ;O B@0=A?>@BC20==O <548G=8E 28@>1V2 4;O 4V03=>AB8:8 in vitro 28:>@8AB>2CNBL B5@<>V7>;NNGV :>=B59=5@8 7 E>;>4>035=B0<8 (0:C<C;OB>@0<8 E>;>4C) 7 B5<?5@0BC@>N 2V4 +2! 4> +8!. !8AB5<0 B@0=A?>@BC20==O <0T 70157?5G8B8 B5<?5@0BC@C =5 28I5 ?;NA +8! B0 =5 =86G5 ?;NA +2! 2 :V=FV <0:A8<0;L=>3> B5@<V=C B@0=A?>@BC20==O. 0< OB09B5, I> 4>B@8<0==O 28<>3 I>4> =0;56=>3> B@0=A?>@BC20==O :><?>=5=BV2 4>=>@AL:>W :@>2V  F5 >48= 7 D0:B>@V2 WE=L>W 157?5G=>W B@0=ADC7VW ?0FVT=BC! 8:>=025FL:0<>2=8::      & ИLNЙҙ֙ $(VZprʚJVln֛؛ $,ʴʴʜh`nHtHh`h5nHtHhf5\nHtHhfB*CJaJphhf56\]hf hf5hfCJaJnHtH hf5\hfCJaJhfnHtHhf5nHtH:ԙ֙ $&bLkd$$If0e e)644 la$If9kdJ$$Ife)644 la $Ifgd,$7`7a$&(VXZpraLkd6$$If0 e)+]644 la$IfLkd$$If0e)644 la~2Lkd$$If0e)644 la $Ifgdj$Ifrkd$$If\ e)Ms 644 laȚʚbU $$If]a$9kd$$Ife)644 la$If$7`7a$Lkdh$$If0@e)644 la $Ifgd,JTaLkdT$$If0e) ~644 la$IfLkd$$If0 e) 644 laTVln;rkd$$If\w Ne)a,2 644 la$IfLkd$$If0w e) 644 larkd$$If\w Ne)a,2 644 la$If؛ڛaXXOOO $$Ifa$$7`7a$Lkd`$$If0e)644 la$IfLkd$$If0e)]+644 la 8_kd$$IfFe){ 1 6    44 la $$Ifa$_kd$$IfFe){ 1 6    44 la_kdh$$IfFe){ 1 6    44 la $$Ifa$ 8_kd$$IfFe){ 1 6    44 la $$Ifa$_kd$$IfFe){ 1 6    44 la "_kdp$$IfFe){ 1 6    44 la $$Ifa$"$&(*Dx̜Μxrrriii]]] $7$8$H$a$gd`^gd`^kd$$Ifr e)^644 la ̜ΜLjr`rz|ޠʼҮxmxmxbUbMDh`\nHtHh`CJaJhhhWQ5B*phhhhWQB*phhWQ5PJnHtHhhhWQ5PJnHtHhhhWQ5\nHtHh`PJnHtHh`56PJ\]nH tH h`PJmH nH sH tH h`PJmHnH sHtH h`nHtHh`5nHtH&hhh`5CJPJ\aJnHtH h`5CJPJ\aJnHtHΜG> 7$8$H$gd`Qkd$$If0m(644 laytx< x$Ifgdx<Qkd\$$If0m(644 laytx< $Ifgdx<Ljt$$7$8$H$If]^a$gdx<$$If]a$gdx<F1% $Ifgdx< $$Ifa$gdx<kd. $$Iflֈ9b]>U"*F9F)FFM t0*44 lBBalytWQFVXZ\ $$Ifa$gdx<\^`1% $$Ifa$gdx<kd $$Iflֈ9b]>U"*G9F)FFM t0*44 lBBalytWQ`prtvx $$Ifa$gdx< $$Ifa$gdx<xz|50'' $Ifgdx<gd`kd $$IflWֈ9b]>U"*9)M t0*44 lalytWQbZ$a$gd`>kdH $$IfR)644 laytx<Qkd $$If0t(R) h644 laytx< $$Ifa$gdx<0<>@DFLNTZ\^x~.6<>BP֢آܣȦ Vīr6ص͵ͱznznznzhfCJaJnHtHhfnHtHhf6CJaJh$\h$\5mHsHhf5CJaJ hf5h,(hXyhfhx[qh4sUh`5\nHtHh]teh`5\h`5\nHtHh`nHtHh`\nHtHh`5nHtHh`6CJaJnHtH+.0246Odkd $$IfF*T  6    44 laytx< $$Ifa$gdx<>$ b @ـ@ހ@@@@@@7$8$H$a$gd`68:<> $Ifgdx< $$Ifa$gdx<dkd $$IfF*T  6    44 laytx<>@BDF~~u $Ifgdx< $$Ifa$gdx<ukdU $$IfF*T  6    44 lapytx<FHJLN~~u $Ifgdx< $$Ifa$gdx<ukd $$IfF*T  6    44 lapytx<NPRTV~~~ $$Ifa$gdx<ukd]$$IfF*T  6    44 lapytx<VXZ\^ $$Ifa$gdx<dkd$$IfF*T  6    44 laytx<tkkkkkkkkkkk^gd`kdD$$Ifr [*644 laytx< ԡ>@BPڣܣD$a$^^gd`DFRޤ&DX $$Ifa$XZ\^`bd@:::::$Ifkd$$IfֈR$e)TP b0644 ladfhjlnp:kdx$$IfֈR$e)TP b0644 la$Ifprtvxz|:kd-$$IfֈR$e)TP b0644 la$If|~$If@:::::$Ifkd$$IfֈR$e)TP b0644 la:888kd$$IfֈR$e)TP b0644 la$IfȦ Vīƫr`bdfhhBD^gd`gd`$a$ ^`dh6^`dtl.68TVJn 68PXZ¾µuukhfPJnH tH hf5\nHtHhf5nHtHhh5hh, hhhv5nHtHhcThv5nHtHhf\nHtHhXyhfhfCJaJnHtHh`h`CJaJnHtHh`nHtHhfnHtHh`hf5 h`5'ȳ68Hڸ0ػʼ8($a$gd$a$gd$a$gdv$a$^ 8:NPRTV_kdL$$IfFe){ 1 6    44 la $$Ifa$$a$ VXZ^`dfjlpr$a$_kd$$IfFe){ 1 6    44 laZ\`bfhlnrhfPJnH tH hfCJaJhK0jhK0U ,1h. A!S"6#7$S%77 H$$If!vh#v #v :V 65 5 a:$$If!vh#v):V 65aV$$If!vh#v #v:V 655/ aV$$If!vh#v#vL$:V 655/ aV$$If!vh#v #v:V 65+5]/ a$$If!vh#v##v#vc#v^:V 655M5s5 / / aV$$If!vh#vJ#v%:V 655/ aV$$If!vh#v#v%&:V 655/ a:$$If!vh#v):V 65aV$$If!vh#v] #vt:V 655 / aV$$If!vh#v#vN#:V 65 5~/ aV$$If!vh#v #v:V 655 / a$$If!vh#v=#v#v#v:V 65a5,525 / / a$$If!vh#v=#v#v#v:V 65a5,525 / / aV$$If!vh#v#v$:V 65]5+/ aV$$If!vh#vV#v{%:V 655/ aV$$If!vh#vL#v#v:V 65{ 551 aV$$If!vh#vL#v#v:V 65{ 551 aV$$If!vh#vL#v#v:V 65{ 551 aV$$If!vh#vL#v#v:V 65{ 551 aV$$If!vh#vL#v#v:V 65{ 551 aV$$If!vh#vL#v#v:V 65{ 551 a$$If!vh#v% #v' #v#v0#v~ :V 655555^/ / ag$$If!vh#v2#v :V 6,55/ aytx<g$$If!vh#v2#v :V 6,55/ aytx<$$Ifl!vh#v9#v)#v#v#v#vM:V l t0*,595)5555M/ BBalytWQ$$Ifl!vh#v9#v)#v#v#v#vM:V l t0*,,,595)5555M/ BBalytWQ$$Ifl!vh#v9#v)#v#v#v#vM:V lW t0*,,,595)5555M/ alytWQS$$If!vh#v(#v:V 65 5haytx<E$$If!vh#v):V 65aytx<a$$If!vh#vG#v(#v:V 65T 55 aytx<a$$If!vh#vG#v(#v:V 65T 55 aytx<$$If!vh#vG#v(#v:V 65T 55 apytx<$$If!vh#vG#v(#v:V 65T 55 apytx<$$If!vh#vG#v(#v:V 65T 55 apytx<a$$If!vh#vG#v(#v:V 65T 55 aytx<}$$If!vh#v! #v& #v(#vX#v :V 655555aytx<$$If!vh#v#v#vT#vP#v #vb:V 06555T5P5 5ba$$If!vh#v#v#vT#vP#v #vb:V 06555T5P5 5ba$$If!vh#v#v#vT#vP#v #vb:V 06555T5P5 5ba$$If!vh#v#v#vT#vP#v #vb:V 06555T5P5 5ba$$If!vh#v#v#vT#vP#v #vb:V 06555T5P5 5baV$$If!vh#vL#v#v:V 65{ 551 aV$$If!vh#vL#v#v:V 65{ 551 a!s0066666668&6FVfv6888&6FVfv&6FVfv&6FVfv&6FVfv&6FVfv&6FVfv8XV~ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@_HmH"nH"sH"tH"F`F  28G09=89CJ_HaJmH"sH"tH"RA R (@8DB 0170FC 70 70<>2GC20==O<fi@f 28G09=0 B01;8FO(:V 44l44l 2k 2 0 5<0T A?8A:C JJ "5:AB C 28=>AFVCJOJQJaJT/T "5:AB C 28=>AFV =0:CJOJQJ^JaJ:' : =0: ?@8<VB:8CJaJ@"@ "5:AB ?@8<VB:8CJaJ>/1> "5:AB ?@8<VB:8 =0:<j!"<  "5<0 ?@8<VB:85\B/QB "5<0 ?@8<VB:8 =0:5\J @bJ 86=V9 :>;>=B8BC;  E$L/qL 86=V9 :>;>=B8BC; =0:CJaJLL 05@E=V9 :>;>=B8BC;  E$N/N 05@E=V9 :>;>=B8BC; =0:CJaJ@U @ 0V?5@?>A8;0==O >*B*phpp !VB:0 B01;8FV7:V0@@ List Paragraph ^L/L A=>2=>9 B5:AB__HfHq xx A=>2=>9 B5:AB1&d,a$$1$-DM CJaJfHq @@ 0Style48$7$1$H$ mHsHtHP/P 1KG=K93 #CJOJPJQJ_HhmHsHtHPK![Content_Types].xmlN0EH-J@%ǎǢ|ș$زULTB l,3;rØJB+$G]7O٭Vyrй<vw{&# wiaY"4qm0՘-:q?ܒsgh'3bfW]f0>9A>^W*6qz֫FҔ4;]?j[V^_+PD+P7WW_KW7 RnK~,WC&^›ׯW2+TC^]r ŶZM  ;b14B% q4›q.UJRˏTDFLƐQBf~^] / J;؊YN 4AIpˮt2)wfö_ [}K4j!Rtz+S$ m_6Ij!Q_ sZaѴhHTmjyV`QP:,DYG<+)oy oٚ!ZHFx0 VMru_n$#g"]Ōm`-keAJ6ZOȻX@xPK! ѐ'theme/theme/_rels/themeManager.xml.relsM 0wooӺ&݈Э5 6?$Q ,.aic21h:qm@RN;d`o7gK(M&$R(.1r'JЊT8V"AȻHu}|$b{P8g/]QAsم(#L[PK-![Content_Types].xmlPK-!֧6 0_rels/.relsPK-!kytheme/theme/themeManager.xmlPK-!9+theme/theme/theme1.xmlPK-! ѐ' theme/theme/_rels/themeManager.xml.relsPK] 1\ 2  27J\6Z3679<lzn "9fWc&T"ΜF\`x6>FNVDXdp|V458:;=mnopqrstuvwxy{|}~'9991\XT8@0(  B S  ? _Hlk60220092 bookmark19 _Hlk123199224$*?2\%*k?2\ ! a s ,;IXE"L"7*<*M*V*W*c*k*t*u********************+ + ++'+1+2+6+7+?+@+D+Q+U+V+]+^+c+d+f+g+m+~++++++++++++++++++++++++, , ,,,,!,-,0,4,5,7,8,A,C,H,I,T,U,Y,Z,b,c,g,t,,,,,,,,,,,,,,,,,,,,,,,,,- --'-.-/-3-9-@-A-D-E-N-R-Z-c-i-j-p-q-s-t-z-}------------------..... .!.%.&.0.4.=.>.I.V.].^.d.f.j.k.s.x........................./ /////&/'/+/D/F/G/P/[/d/r/{/|/////////////////////////000000080@0A0K0L0P0T0[0f0j0k0w0x000000000000000111111#1&1.131<1G1K1L1U1]1d1h1v1{1111111111111111111111111111122222!2,24272E2N2R2U2]2f2g2r2s2w2x222222222222222222222222223 3333"3#3/3034363>3?3K3L3R3S3\3a3f3h3j3k3o3p3u3y333333333333333333333333334 4 4444 4&4'4.4045484>4C4H4I4M4P4X4]4f4i4p4s4y44444444444444444444444444 5 55555%5&5-5.5;5<5G5K5P5Q5\5]5i5j5s5t5y5z5555555555555555555555556 6 66666!6"6,6-60616;6<6B6K6W6X6[6]6d6g6q6s666666666666666666666777777!7%7071747B7K7V7_7d7n7o7x7y777777777777777777777888888)8*8.8084858<8@8J8K8O8P8T8U8`8c8p8|888888888888888888888888 99999&9'999999999999999999999::::::!:":+:.:7:8:>:?:F:b:f:g:r:s:|:}:::::::::::::::::::::;;;;+;0;5;6;>;M;Q;R;T;U;];o;q;r;|;;;;;;;;;;;;;;;;;;;;;<<<<<#<&<*<2<;<<<G<H<L<M<U<e<h<u<}<<<<<<<<<<<<<<<<<<<<<<<====='=+=0===2>6>:>=>k>n>>>>>CCYK[K\KaKKKKKELGLHLMLLLLL2O4O5O:OPPPPPP:QHQ.R8RUUXXhYuYZZZ ZWZYZZZ_ZoZ|Z\\\\\\ \"\#\/\2\ %'-2BC)*CEZ[  ` a f g AB'(89deEFklY[yz9: W!X!l"m"##$$w%x%''-'/'''<(>(V(W(((k)l)**0*1*7*u.x.../12233@4A455"7#7y8z89^<h<:=Q=R===========>>!>#>->0>7>:>?>C>M>O>h>k>u>x>>>>>>>>>>>>>>>>>>? ? ?%?&?B?D?O?Q?\?_?h?l?w?x??????????? @@@@!@(@@RAYA\AfAjAuAwAAAAAAAAAB BBB[B]BBBBB C CCCXCYCkClC|C}CCCCCCCMD{DDkEFNFFF"GGG*HH IBJJJJJJKK KKaKcKKKVMWMNNNNNOOOPPwSxSUUXXXXYY[[^[i[j[[[\\\\\\\\\ \"\#\-\/\2\33 %C*1*:=R========>>.>0>8>:>@>C>>?]?_??@@@#@RAAAABCYCkE#GGJJ[\\\\\\\ \"\#\-\/\2\2 :t=&'%&^kEE-'.'|(((($*:=======>>.>.>8>8>@>@>>>>>>>?l???@@@ABBGGGGGFJJJJKK][\\\2\jQV ^`o(. ^`hH. pL^p`LhH. @ ^@ `hH. ^`hH. L^`LhH. ^`hH. ^`hH. PL^P`LhH.j""""""""";AaT{W,J.Oik7!(IJpX ry{` = ! 0 v- 2 CL   `^ mr )D] [ 'Q:O xG%X\kH,/\_Ial 6'i o /gS_)[]"[v|;IMA!!a&!0n!H"e"R#H##<#J$1j$q$%dM%G&HT&'2e'|',(a(uo(8).=[.}./1/K0z"12N#26W2o23L344,4H-5F5vc56d#7L7c7?8!9Gg:;*;2;^;#r; <l<M7<=]_=9t=A>.@Y\L]2b]^.^_2``s"`eaha60cz3cZcdc EdRdgd~wde-eDeZeWceo h]ij^Wj`jqkblZlalpRmRmhm`ncnCln{oPp`prqx[qEEsJsobs#t,t1t uFu luvv$4vQ6vewwjqwx.x:JxnoxBRy VyXy~`yz%zr{C|]|m|= }Ah}&~:~w~lrvf flp!tYM'+o8e. %`FT $-I$gsx+EvBSYzQ .;) -]2=z| 7kpR$;;&>J@BfJ  W@N&1#Dt[1_GKx5%]]o"Gj]^<o>st-=z@/rsYSIano  9@=IIaKL)+~m%B*AQH9d)f;X8, )0v>-xv;^kvr]# 3P;s%jpx<PWQ ^wck[v x /9<~` |GSu*zC<sAKRRBx.3rtLR$%-z% I{:Eq77pq[gD \/[v+UB%T~g1 GMSDU$_g^1P{tvvkTYXM$[exY!d/fLo?v6Mrq#e0}wD[]\\ 7ag!Lw^vS0o4>s-%({m )bZs)- |7/~>(J5JS Iz'>c3wcW\\@(.1\hh h|Unknown G.[x Times New Roman5Symbol3. .[x ArialUNunitoTimes New Roman7..{$ Calibri_TimesNewRomanPSMTMS Mincho9. . Segoe UI[$UkrainianPragmaticaArialG  MS Mincho-3 fgA$BCambria Math Aô'Gg:p! /G:p! /G!\(!),.:;?]}    & 6"0000 0 0 00000 =@\]^([{  0 0 00000;[S720[[ KqP ?.^2! xx EXSPED :>=><VAB1 Oh+'0l   ( 4 @LT\dEXSPEDNormal 129Microsoft Office Word@J.@ !I@\ϓv@doei :p!՜.+,D՜.+,P  hp  KMBCG/[   @t _PID_HLINKS!lcf76f155ced4ddcb4097134ff3c332f TaxCatchAllKSOProductBuildVerICVAm+4https://zakon.rada.gov.ua/laws/show/382-2023-%D0%BFText1033-11.2.0.11440$B21C8BC4DB6F4570BE3916DDC01F7E85  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~Root Entry F0jeiData 1Table;QWordDocument.2SummaryInformation(DocumentSummaryInformation8CompObjr  F Microsoft Word 97-2003 MSWordDocWord.Document.89q